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US 2003/0082736 A1Published application
Fusion proteins comprising tumor necrosis factor receptor
AssigneeImmunex Corporation
InventorCraig A. Smith
Life of this patent
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Abstract
Fusion proteins comprise a tumor necrosis factor receptor (TNF-R) polypeptide and at least one additional polypeptide selected from an interleukin-1 receptor (IL-1R) and a second TNF-R polypeptide. One such fusion protein comprises one IL-1R and two TNF-R polypeptides. The fusion proteins have therapeutic use and may be produced via recombinant DNA technology.
Claims26
A fusion protein comprising a human tumor necrosis factor receptor (TNF-R) and a human interleukin-1 receptor (IL-1R).
A fusion protein of the formula:
- TNF-R−linker−TNF-R
- wherein the linker is a peptide linker.
Dependencies are inferred from the claim text.