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US 2003/0079239 A1Published application
Gene Associated with bone disorders
OwnerNeelam Jaiswal, Adam Houghton +4inventors
InventorsNeelam Jaiswal, Adam Houghton, Lawrence Mertz, Darren Ji, Jonathan S. Cook, Douglas W. Axelrod
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Abstract
The present invention relates to identifying genes that are differentially regulated or expressed in bone deposition disorders. Specifically, a novel gene has been identified as being differentially regulated during the maturation of osteoblasts and whose expression can be correlated, for example, with bone deposition disorders such as osteoporosis.
Claims23
An isolated nucleic acid molecule selected from the group consisting of:
- (a) an isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 1;
- (b) an isolated nucleic acid molecule encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2;
- (c) an isolated nucleic acid molecule that encodes a polypeptide fragment of at least 364 amino acids of SEQ ID NO:
- 2;
- (d) an isolated nucleic acid molecule that exhibits at least 55% identity over the entire contiguous nucleotide sequence of SEQ ID NO:
- 1;
- (e) an isolated nucleic acid molecule that exhibits at least 83% identity over the entire contiguous sequence of nucleotides 319-1533 of SEQ ID NO:
- 1;
- and
- (f) an isolated nucleic acid molecule that encodes a polypeptide that exhibits at least 90% identity over the entire contiguous amino acid sequence of SEQ ID NO:
- 2.
10 more elements
An isolated polypeptide selected from the group consisting of:
- (a) an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2;
- (b) an isolated polypeptide comprising a fragment of at least 364 amino acids of SEQ ID NO:
- 2;
- and
- (c) an isolated polypeptide exhibiting at least 90% identity over the entire contiguous amino acid sequence of SEQ ID NO:
- 2.
4 more elements
Dependencies are inferred from the claim text.