Serine protease inhibitors

A serine protease inhibitor compound of formula (I)

• 28
• wherein:
• R2 is a 5 or 6 membered aromatic carbon ring optionally interrupted by a nitrogen, oxygen or sulphur ring atom, optionally being substituted in the 3 and/or 4 position (in relation to the point of attachment of X-X) by halo, nitro, thiol, haloalkoxy, hydrazido, alkylhydrazido, amino, cyano, haloalkyl, alkylthio, alkenyl, alkynyl, acylamino, tri or difluoromethoxy, carboxy, acyloxy, MeSO2— or R1, or the substituents at the 3 and 4 positions taken together form a fused ring which is a 5 or 6 membered carbocyclic or heterocyclic ring optionally substituted by halo, haloalkoxy, haloalkyl, cyano, nitro, amino, hydrazido, alkylthio, alkenyl, alkynyl or R1j, and optionally substituted in the position alpha to the X-X group (i.e. 6 position for a six membered aromatic ring etc) by amino, hydroxy, halo, alkyl, carboxy, alkoxycarbonyl, cyano, amido, aminoalkyl, alkoxy or alkylthio with the proviso that R2 cannot be aminoisoquinolyl;
• each X independently is a C, N, O or S atom or a CO, CR1a, C(R1a)2 or NR1a group, at least one X being C, CO, CR1a or C(R1a)2;
• each R1a independently represents hydrogen, hydroxyl, alkoxy, alkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkylaminocarbonyl, alkoxycarbonylamino, acyloxymethoxycarbonyl or alkylamino optionally substituted by hydroxy, alkylamino, alkoxy, oxo, aryl or cycloalkyl;
• R1 is as defined for R1a, provided that R1 is not unsubstituted aminoalkyl;
• Y (the α-atom) is a nitrogen atom or a CR1b group;
• Cy is a saturated or unsaturated, mono or poly cyclic, homo or heterocyclic group, optionally substituted by groups R3a or R3iXi;
• each R3a independently is R1c, amino, halo, cyano, nitro, thiol, alkylthio, alkylsulphonyl, alkylsulphenyl, triazolyl, imidazolyl, tetrazolyl, hydrazido, alkylimidazolyl, thiazolyl, alkylthiazolyl, alkyloxazolyl, oxazolyl, alkylsulphonamido, alkylaminosulphonyl, aminosulphonyl, haloalkoxy, haloalkyl, a group of the formula —C(X3)N(R11)R12 (wherein X3 is O or S;
• and R11 and R12 are independently selected from hydrogen, methyl or ethyl or together with the nitrogen atom to which they are attached form a pyrrolidin-1-yl, piperidin-1-yl or morpholino group), or —OCH2O— which is bonded to two adjacent ring atoms in Cy;
• Xi is a bond, O, NH or CH2;
• R3i is phenyl, pyridyl or pyrimidinyl optionally substituted by R3a;
• and
• R1b, R1c and R1j are as defined for R1a, and -L-Lp(D)n is of the formula:
• 29
• wherein:
• q is 1 or 2;
• Q is —O— or —NH—;
• and Rq is Rc which is pyridyl, pyrimidin-4-yl, pyridazin-3-yl, pyridazin-4-yl or phenyl (which phenyl or pyridyl group may bear a fluoro, chloro, alkyl, CONH2, SO2NH2, dialkylaminosulphonyl, methoxy, methylthio, alkylsulphonyl, alkylaminosulphonyl, alkylaminocarbonyl, amino, alkoxycarbonyl, acetylamino, cyano, ethoxy, nitro, hydroxy, alkylsulphonylamino, triazolyl or tetrazolyl substituent);
• or a physiologically-tolerable salt thereof.