Composition for treating or preventing glomerulopathy
AssigneeShionogi & Co., Ltd.
InventorsHidetake Kurihara, Fumihiko Watanabe, Yoshinori Tamura, Toshihiro Sinosaki
Life of this patent
Estimating the term…
Abstract
A composition for treating or preventing glomerulopathy which contains a compound of the formula (1): 1 wherein, for example, R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aralkyl, etc.; R3 is 1,4-phenylene and 2,5-thiophendiyl; R4 is the substituents represented by the formula, etc.: 2 wherein R6 is hydrogen atom, optionally substituted amino, etc.; and Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
Claims39
A composition for treating or preventing glomerulopathy which contains a compound of the formula (I):
- 236
- wherein R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroarylalkyl;
- R3 is 1,4-phenylene or 2,5-thiophendiyl;
- R4 is a substituent represented by the formula:
- 237
- wherein R5 is hydrogen atom, hydroxy, optionally substituted lower alkyloxy, mercapto, lower alkylthio, cycloalkyl, halogen, carboxy, lower alkyloxycarbonyl, nitro, cyano, lower holoalkyl, aryloxy, optionally substituted amino, guanidino, optionally substituted lower alkyl, lower alkenyl, lower alkynyl, acyl, acyloxy, —CONRARB, —N(Rc)CORD (wherein RA, RB, and RC are the same or different selected from hydrogen atom, lower alkyl, and aralkyl;
- RD is lower alkyl, aryl, or aralkyl), optionally substituted non-aromatic heterocyclic group, or optionally substituted heteroaryl;
- R6 is optionally substituted lower alkyl, cycloalkyl, lower alkyloxy, halogen, lower alkylthio, optionally substituted amino, carboxy, lower alkyloxycarbonyl, aryloxy, phenyl, optionally substituted non-aromatic heterocyclic group, or optionally substituted heteroaryl;
- and
- Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (II):
- 238
- wherein R1, R2, and R3 are as defined above;
- R7 is a substitution represented by the formula:
- 239
- wherein R8 is hydrogen atom, hydroxy, lower alkyloxy, mercapto, lower alkylthio, cycloalkyl, halogen, carboxy, lower alkyloxycarbonyl, nitro, cyano, lower haloalkyl, aryloxy, optionally substituted amino, guanidino, optionally substituted lower alkyl, lower alkenyl, lower alkynyl, alkanoyl, acyloxy, or optionally substituted heteroaryl;
- R9 is optionally substituted lower alkyl, cycloalkyl, carboxy, lower alkyloxycarbonyl, aryloxy, or phenyl;
- and
- Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (I):
- 240
- wherein R1, R2, and R3 are as defined above:
- R4 is a substituent represented by the formula:
- 241
- wherein R10 is hydrogen atom, optionally substituted lower alkyloxy, lower alkylthio, halogen, optionally substituted amino, optionally substituted lower alkyl, or optionally substituted non-aromatic heterocyclic group;
- R11 is optionally substituted lower alkyl, lower alkylthio, halogen, optionally substituted amino, phenyl, optionally substituted non-aromatic heterocyclic group, or optionally substituted heteroaryl;
- and
- Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains-a compound of the formula (II):
- 242
- wherein R1, R2, and R3 are as defined above;
- R7 is a substituent represented by the formula:
- 243
- wherein R12 is hydrogen atom, halogen, nitro, optionally substituted lower alkyl, lower alkyloxy, you or lower alkylthio;
- R13 is optionally substituted lower alkyl or phenyl;
- and
- Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (III):
- 244
- wherein R1, R10, and Y are as defined above;
- and R14 is hydrogen atom or lower alkyl, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof
A composition for treating or preventing glomerulopathy-which -contains a compound of the formula (IV):
- 245
- wherein R1, R12, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt., or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (V):
- 246
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains-a compound of the formula (VI):
- 247
- wherein R1, R12, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (VI):
- 248
- wherein R1, R2, R3, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains-a compound of the formula (VIII):
- 249
- wherein R1, R12, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (IX):
- 250
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (X):
- 251
- wherein R1, R12 R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XI):
- 252
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains-a compound of the formula (XII):
- 253
- wherein R1, R12, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XIII):
- 254
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XIV):
- 255
- wherein R1, R12, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XV):
- 256
- wherein R1, R11, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XVI):
- 257
- wherein R1, R13, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of the formula (XVII):
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of formula (XVIII):
- 258
- wherein R1, R10, R 14, and Y are as defined above, its opitcally active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of the formula (XIX):
- 259
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of the formula (XX):
- 260
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of the formula (XXI):
- 261
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of the formula (XXII):
- 262
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A compound of the formula (XXIII):
- 263
- wherein R1, R10, R14, and Y are as defined above, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XXIV):
- 264
- wherein the combination of each substituent is represented below, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
- 18 TABLE 1 Compound No. Y R1 R2 R15 1 NHOH (CH3)2CH— H 265 2 NHOH (CH3)2CH— Me 266 3 OH 267 H 268 4 NHOH 269 H 270 5 OH (CH3)2CH— H 271 6 OH PhCH2— H 272 7 OH (CH3)2CH— H 273 8 OH 274 H 275 9 NHOH (CH3)2CH— H 276 10 OH (CH3)2CH— H 277 11 OH (CH3)2CH— H 278 12 OH PhCH2— H 279 13 OH (CH3)2CH— H 280 14 OH 281 H 282 15 OH (CH3)2CH— H 283 16 OH (CH3)2CH— H 284 17 OH PhCH2— H 285 18 OH PhCH2— H 286 19 OH CH3— H 287 20 OH PhCH2— H 288 21 OH PhCH2— H 289 22 OH CH3— H 290 23 OH PhCH2— H 291 24 OH CH3— H 292 25 OH (CH3)2CH— H 293 26 OH (CH3)2CH— H 294 27 OH (CH3)2CH— H 295 28 OH H H 296 29 OH H H 297 30 OH 298 H 299 31 OH (CH3)2CH— H 300 32 OH PhCH2— H 301 33 NHOH PhCH2— H 302 34 OH PhCH2— H 303 35 OH 304 H 305 36 OH 306 H 307 37 OH 308 H 309 38 OH (CH3)2CH— H 310 39 OH (CH3)2CH— H 311 40 OH 312 H 313 41 OH PhCH2— H 314 42 NHOH (CH3)2CH— H 315 43 OH PhCH2— H 316 44 OH PhCH2— H 317 45 OH (CH3)2CH— H 318 46 OH (CH3)2CH— H 319 47 OH (CH3)2CH— H 320 48 OH PhNHCO(CH2)2— H 321 49 OH PhCH2— H 322 50 OH PhCH2— H 323 51 OH (CH3)2CH— H 324 52 OH (CH3)2CHCH2— H 325 53 OH (CH3)2CH— H 326 54 OH (CH3)2CH— H 327 55 OH (CH3)2CH— H 328 56 OH (CH3)2CH— H 329 57 OH CH3— H 330 58 OH (CH3)2CH— H 331 59 OH MeS—CH2CH2— H 332 60 OH 4-OH—Ph— H 333 61 OH PhCH2— H 334 62 OH PhCH2— H 335 63 OH (CH3)2CH— H 336 64 OH (CH3)2CH— H 337 65 NHOH (CH3)2CH— H 338 66 OH PhCH2— H 339 67 OH PhCH2— H 340 68 OH 341 H 342 69 OH 343 H 344 70 NHOH 345 H 346 71 NHOH (CH3)2CH— H 347 72 NHOH 348 H 349 73 OH 350 H 351 74 OH (CH3)2CH— H 352 75 OH (CH3)2CH— H 353 76 OH 354 H 355 77 OH PhCH2— H 356 78 OH 357 H 358 79 OH (CH3)2CH— H 359 80 NHOH 360 H 361 81 OH 362 H 363 82 OH 364 H 365 83 OH 366 H 367 84 OH (CH3)2CH— H 368 85 OH PhCH2— H 369 86 OH 370 H 371 87 OH PhCH2— H 372 88 OH 373 H 374 89 NHOH 375 H 376 90 OH 377 H 378 91 OH 379 H 380 92 OH 381 H 382 93 OH PhCH2— H 383 94 OH PhCH2— H 384 95 OH PhCH2— H 385 96 OH (CH3)2CH— H 386 97 OH (CH3)2CH— H 387 98 OH (CH3)2CH— H 388 99 OH (CH3)2CH— H 389 100 OH (CH3)2CH— H 390 101 OH (CH3)2CH— H 391 102 OH (CH3)2CH— H 392 103 OH (CH3)2CH— H 393 104 OH (CH3)2CH— H 394 105 OH PhCH2— H 395 106 OH (CH3)2CH— H 396 107 OH (CH3)2CH— H 397 108 OH PhCH2— H 398 109 OH 399 H 400 110 OH PhCH2— H 401 111 OH 402 H 403 112 OH (CH3)2CH— H 404 113 OH (CH3)2CHCH2— H 405 114 OH CH3— H 406 115 OH PhCH2— H 407 116 OH H H 408 117 OH CH3— H 409 118 OH (CH3)2CH— H 410 119 OH (CH3)2CH— H 411 120 OH (CH3)2CH— H 412 121 OH (CH3)2CH— H 413
A composition for treating or preventing glomerulopathy which contains a compound of the formula (XXIV):
- 414
- wherein the combination of each substituent is represented below, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
- 19 TABLE 2 Compound No. Y R1 R2 R15 1 NHOH (CH3)2CH— H 415 2 NHOH (CH3)2CH— Me 416 3 OH 417 H 418 4 NHOH 419 H 420 5 OH (CH3)2CH— H 421 6 OH PhCH2— H 422 7 OH (CH3)2CH— H 423 31 OH (CH3)2CH— H 424 32 OH PhCH2— H 425 33 NHOH PhCH2— H 426 34 OH PhCH2— H 427 35 OH 428 H 429 36 OH 430 H 431 37 OH 432 H 433 38 OH (CH3)2CH— H 434 39 OH (CH3)2CH— H 435 63 OH (CH3)2CH— H 436 64 OH (CH3)2CH— H 437 65 NHOH (CH3)2CH— H 438 66 OH PhCH2— H 439 67 OH PhCH2— H 440 68 OH 441 H 442 69 OH 443 H 444 70 NHOH 445 H 446 71 NHOH (CH3)2CH— H 447 72 NHOH 448 H 449 88 OH 450 H 451 89 NHOH 452 H 453 90 OH 454 H 455 91 OH 456 H 457 92 OH 458 H 459 93 OH PhCH2— H 460 94 OH PhCH2— H 461
Dependencies are inferred from the claim text.