Back to results
US 2003/0078293 A1Published application
Use of etodolac for the treatment of chronic lymphocytic leukemia
AssigneeThe Regents of the University of California
InventorsDennis A. Carson, Howard B. Cottam, Souchi Adachi, Lorenzo M. Leoni
Life of this patent
Estimating the term…
Abstract
A method of treating cancer is provided comprising administering an amount of etodolac to a subject afflicted with cancer that is effective to reduce the viability and/or to sensitize the cancer to an anti-cancer agent.
Claims12
A method of treating prostate cancer in a mammal comprising contacting the cancer cells with a compound of formula (II):
- 3
- wherein R1 is lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, phenyl or benzyl, R2, R3, R4 and R5 are the same or different and are each hydrogen or lower alkyl;
- R6 is hydrogen, lower alkyl, hydroxy, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, R7 is hydrogen, lower alkyl or lower alkenyl;
- X is oxy;
- Y is carbonyl or (C1-C3)alkyl(CO), wherein each alkyl is substituted with 0-2 (C1-C4) alkyl, and Z is hydroxy, lower alkoxy, amino, lower alkylamino, di(lower)alkylamino or phenylamino, or a pharmaceutically acceptable salt thereof,
- effective to reduce the viability of the cancerous prostate cells.
3 more elements
A method of increasing the susceptibility of prostate cancer cells in a mammal to a chemotherapeutic agent comprising contacting the cells with a compound of formula (II):
- 4
- wherein R1 is lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, phenyl or benzyl, R2, R3, R4 and R5 are the same or different and are each hydrogen or lower alkyl;
- R6 is hydrogen, lower alkyl, hydroxy, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, R7 is hydrogen, lower alkyl or lower alkenyl;
- X is oxy;
- Y is carbonyl or (C1-C3)alkyl(CO), wherein each alkyl is substituted with 0-2 (C1-C4) alkyl, and Z is hydroxy, lower alkoxy, amino, lower alkylamino, di(lower)alkylamino or phenylamino, or a pharmaceutically acceptable salt thereof,
- effective to sensitize the cancerous prostate cells.
3 more elements
Dependencies are inferred from the claim text.