Allergy vaccines and their preparation
OwnerMargarete Focke, Vera Mahler +4inventors
InventorsMargarete Focke, Vera Mahler, Wolfgang R. Sperr, Peter Valent, Dietrich Kraft, Rudolf Valenta
Life of this patent
Estimating the term…
Abstract
The present invention relates to a pharmaceutical composition containing a peptide and a pharmaceutically acceptable carrier or diluent wherein the peptide has a length of 8 to 50 amino acids, at least three preferably consecutive amino acids of the peptide are identical to at least three amino acids which appear in close vicinity on the molecular surface of an allergenic protein, and said at least three amino acids are solvent-exposed amino acids in the allergenic protein. The invention also concerns a method for the preparation of the pharmaceutical composition.
Claims27
A pharmaceutical composition containing a peptide and a pharmaceutically acceptable carrier or diluent wherein
- a) the peptide has a length of 8 to 50 amino acids;
- b) at least three preferably consecutive amino acids of the peptide are identical to at least three amino acids which appear in close vicinity on the molecular surface of an allergenic protein;
- c) said at least three amino acids are solvent-exposed amino acids in the allergenic protein.
A method for the preparation of a pharmaceutical composition comprising the following steps:
- a) determining which amino acids of a given allergenic protein are solvent-exposed on the surface of the allergenic protein;
- b) preparing a peptide having a length of 8 to 50 amino acids wherein at least three preferably consecutive amino acids of the peptide are identical to at least three amino acids which appear in close vicinity on the molecular surface of an allergenic protein wherein the at least three amino acids are solvent-exposed amino acids in the allergenic protein;
- and
- c) optionally admixing the peptide with a pharmaceutically acceptable carrier or diluent.
The use of a peptide which has a length of 8 to 50 amino acids wherein at least three preferably consecutive amino acids of the peptide are identical to at least three amino acids which appear in close vicinity on the molecular surface of an allergenic protein with the at least three amino acids being solvent-exposed amino acids in the allergenic protein for the preparation of a medicament for the treatment of an allergic disease.
Dependencies are inferred from the claim text.