Zvwf1: a member of the von Willebrand factor type a domain superfamily
OwnerJames L. Hollowayinventor
Life of this patent
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Abstract
Proteins comprising one or more copies of von Willebrand factor type A domain play important roles in host defense mechanisms, such as immune response, inflammation, and hemostasis. Zvwf1 is a new member of this superfamily.
Claims20
An isolated polypeptide, comprising an amino acid sequence that is at least 70% identical to a reference amino acid sequence selected from the group consisting of:
- the amino acid sequence of SEQ ID NO:2, amino acid residues 1 to 49 of SEQ ID NO:2, amino acid residues 5 to 186 of SEQ ID NO:2, amino acid residues 1 to 223 of SEQ ID NO:2, and amino acid residues 207 to 328 of SEQ ID NO:2, wherein the isolated polypeptide specifically binds with an antibody that specifically binds with a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
An isolated nucleic acid molecule, wherein the nucleic acid molecule is selected from the group consisting of (a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:3, (b) a nucleic acid molecule that remains hybridized following stringent wash conditions to a nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
- (i) nucleotides 1 to 147 of SEQ ID NO:1, (ii) nucleotides 1 to 669 of SEQ ID NO:1, (iii) nucleotides 1 to 987 of SEQ ID NO:1, and (iv) a nucleotide sequence that is the complement of the nucleotide sequence of (i), (ii), or (iii).
An isolated polypeptide, comprising an amino acid sequence selected from the group consisting of:
- the amino acid sequence of SEQ ID NO:2, amino acid residues 1 to 49 of SEQ ID NO:2, amino acid residues 1 to 223 of SEQ ID NO:2, amino acid residues 5 to 186 of SEQ ID NO:2, and amino acid residues 207 to 328 of SEQ ID NO:2.
Dependencies are inferred from the claim text.