Human tissue urokinase type plasminogen activator formulation
OwnerPaul Porwen Hung, Kenneth S. S. Chang +2inventors
InventorsPaul Porwen Hung, Kenneth S. S. Chang, Bryan T. H. Wu, Kuo-Kuei Huang
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Abstract
This invention relates to an anhydrous arginine-free formulation including human tissue urokinase type plasminogen activator, lysine, phosphoric acid, and a non-ionic detergent, wherein the human tissue urokinase type plasminogen activator, lysine, phosphoric acid, and non-ionic detergent are in quantities of 10-60 mg, 100-700 mg, 20-100 mg, and 0.2-5 mg, respectively; or in quantities of the same relative ratio.
Claims24
An anhydrous arginine-free formulation comprising:
- human tissue urokinase type plasminogen activator;
- lysine;
- phosphoric acid;
- and
- a non-ionic detergent;
- wherein the human tissue urokinase type plasminogen activator, lysine, phosphoric acid, and non-ionic detergent are in quantities of 10-60 mg, 100-700 mg, 20-100 mg, and 0.2-5 mg, respectively;
- or in quantities of the same relative ratio.
An anhydrous arginine-free formulation comprising 5-20% by weight human tissue urokinase type plasminogen activator and 55-85% by weight lysine.
Dependencies are inferred from the claim text.