Streptococcus antigens
AssigneeID Biomedical Corporation
InventorsJosee Hamel, Catherine Ouellet, Nathalie Charland, Denis Martin, Bernard Brodeur
Life of this patent
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Abstract
Streptococcus polypeptides and polynucleotides encoding them are disclosed. Said polypeptides may be useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
Claims34
An isolated polynucleotide comprising a polynucleotide chosen from;
- (a) a polynucleotide encoding a polypeptide having at least 70% identity to a second polypeptide chosen from:
- table B, E or H;
- (b) a polynucleotide encoding a polypeptide having at least 95% identity to a second polypeptide chosen from:
- table B, E or H;
- (c) a polynucleotide encoding a polypeptide having an amino sequence chosen from table B, E or H or fragments, analogs or derivatives thereof;
- (d) a polynucleotide encoding a polypeptide chosen from:
- table B, E or H;
- (e) a polynucleotide encoding a polypeptide capable of generating antibodies having binding specificity for a polypeptide having a sequence chosen from:
- table B, E or H,
- (f) a polynucleotide encoding an epitope bearing portion of a polypeptide chosen from table B, E or H;
- and
- (g) a polynycleotide complementary to a polynucleotide in (a), (b), (c), (d), (e) or (f).
An isolated polypeptide comprising a member chosen from:
- (a) a polypeptide having at least 70% identity to a second polypeptide having an amino acid sequence chosen from:
- table B, E or H;
- (b) a polypeptide having at least 95% identity to a second polypeptide having an amino acid sequence chosen from:
- table B, E or H;
- (c) a polypeptide having an amino acid sequence chosen from table B, E or H;
- (d) a polypeptide having amino acid sequence chosen from:
- table B, E or H or fragments, analogs or derivatives thereof;
- (e) a polypeptide capable of generating antibodies having binding specificity for a second polypeptide having a sequence chosen from table B, E or H;
- (f) an epitope bearing portion of a polypeptide having an amino acid sequence chosen from:
- table B, E or H;
- (g) the polypeptide of (a), (b), (c), (d), (e), or (f) wherein wherein the N-terminal Met residue is deleted;
- or
- (h) the polypeptide of (a), (b), (c), (d), (e), or (f) wherein the secretory amino acid sequence is deleted.
A chimeric polypeptide comprising two or more polypeptides chosen from table B, E or H thereof;
- provided that the polypeptides are linked as to form a chimeric polypeptide.
Dependencies are inferred from the claim text.