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US 2003/0077282 A1Published application
Use of bispecific antibodies to regulate immune responses
OwnerMichael Eric Bigler, Holly Marie Cherwinski +1inventors
InventorsMichael Eric Bigler, Holly Marie Cherwinski, Joseph H. Phillips
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Abstract
The invention relates generally to the field of immunology, in particular, to bispecific antibodies. Methods for designing a bispecific antibody for use in treating diseases relating to the immune system are disclosed. Specific examples relate to bispecific antibodies which recognize an activating receptor and an inhibiting receptor.
Claims17
A method for using a bispecific antibody to reduce the activity of a cell or of an activating receptor, wherein said bispecific antibody binds to:
- (a) an activating receptor;
- and
- (b) an inhibiting receptor.
Dependencies are inferred from the claim text.