Plasmon resonance sensor
AssigneeJandratex GmbH
InventorAndreas Hofmann
Life of this patent
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Abstract
The invention relates to a plasmon resonance sensor that comprises collimator optics (13) in the form of a cylindrical lens that is interposed between the laser diode (7) and the prism (1), said prism being provided with a reflective metal layer (5). This arrangement preserves the beam divergence in the plane of incidence that comprises all angles of incidence that are potentially possible for a resonance and that are detected by the detector (8). In a plane perpendicular to the plane of incidence the beam path is collimated, thereby allowing for a compact design and for the simultaneous arrangement of a plurality of measuring cells that are arranged perpendicular to the plane of incidence one behind the other.
Claims9
A plasmon resonance sensor for biological, biochemical or chemical tests, with an optically transparent body (1, 17), in particular a glass prism, a reflective metal layer (5) or semiconductor layer which is applied to one face (4) of the body (1, 17) and has a surface (6) sensitive to molecules to be detected in a sample, which forms a measurement cell in conjunction with a cuvette, a monochromatic light source (7, 15, 34 to 37, 51 to 54), in particular a laser diode, for emitting a divergent light pencil or beam path (9, 26 to 29, 39 to 42, 59 to 62) through the optically transparent body (1, 17) onto the inner face of the layer (5), and a detector (8, 22 to 25, 43 to 46, 63 to 66) which is assigned to the emerging beam path (11) reflected by the layer (5) and registers as a function of time the light emergence angle, which changes as a result of molecule buildup on the sensitive surface (6), at which an emerging light intensity minimum occurs owing to resonance, characterized in that collimation optics (13, 16, 38, 55 to 58), which collimate the incident beam path (10) perpendicularly to the incidence plane (12) but still leave it divergent in the incidence plane (12), are arranged between the light source (7, 15, 34 to 37, 51 to 54) and the optically transparent body (1, 17).
Dependencies are inferred from the claim text.