Novel compounds having antiviral activity
AssigneeNissin Food Products Co., Ltd.
InventorsShuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Abstract
In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.
Claims29
A method of treating a virus-mediated disease in a mammal comprising administering to said mammal a sulfated sialyl lipid compound, or the salt thereof wherein said sulfated sialyl lipid compound or salt thereof comprises:
- a monosaccharide moiety linked to a lipid moiety, wherein said monosaccharide moiety is a sialic acid or 2-keto-3-deoxy-D-glycero-2-nonuloic acid (KDN), and said lipid moiety is linked to the anomeric carbon of said sialic acid or said KDN, and all hydroxyl groups of said sialic acid or said KDN are sulfated.
A compound or the salt thereof which is a glycoside comprising a monosaccharide-lipid, wherein said lipid moiety is linked to the anomeric carbon of sialic acid or KDN, and all the hydroxyl groups of said sialic acid moiety or KDN moiety are sulfated,
- wherein said compound is sodium(2,2-bis(docosyloxymethyl)propyl 5-acetamido-3,5-dideoxy-4,7,8,9-tetra-O-(sodium oxysulfonyl)-D-glycero-α-D-galacto-2-nonulopyranosid)onate or an acid form thereof.
Dependencies are inferred from the claim text.