Modified bdnf
AssigneeLTT Bio-Pharma Co., Ltd.
InventorsRie Igarashi, Yutaka Mizushima, Mutsuo Taiji, Chikao Nakayama, Hiroshi Noguchi
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Abstract
Modified BDNF having improved pharmacological activities, pharmacokinetics and physical properties can be obtained by modifying BDNF with a 1-acyl-glycerol derivative. This BDNF being modified with a 1-acyl-glycerol derivative of the present invention has more efficacious and more excellent pharmacokinetic properties with retaining the useful effects being characteristic to BDNF which are useful as remedies for neurodegenerative diseases and diabetes mellitus, and hence, it is particularly useful as a therapeutic agent for treatment of type 2 diabetes mellitus.
Claims11
A brain-derived neurotrophic factor being modified with a 1-acyl-glycerol derivative.
A therapeutic agent for treatment of type 2 diabetes mellitus, which comprises as the active ingredient a modified brain-derived neurotrophic factor of the formula (1):
- A (X-B)m (1)
- wherein A is a residue of brain-derived neurotrophic factor,
- B is a residue of a 1-acyl-glycerol derivative having a hydroxyl group at the 2-position of the glycerol moiety, which is prepared by removing a hydrogen atom from the hydroxyl group,
- X is a chemical cross-linkage, and
- m is an average number of the introduction and is not less than about 0.5.
Dependencies are inferred from the claim text.