Novel cationic lipopolymer as biocompatible gene delivery agent
OwnerRam I. Mahato, Sang-Oh Han +1inventors
InventorsRam I. Mahato, Sang-Oh Han, Darin Y. Furgeson
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Abstract
A biodegradable non-toxic cationic lipopolymer comprising a branched polyethylenimine (PEI), a lipid anchor, biocompatible hydrophilic polymer spacer, and a biodegradable linker which covalently links the branched PEI, the spacer and the cholesterol derived lipid anchor. The cationic lipopolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
Claims35
A biodegradable non-toxic cationic lipopolymer comprising a branched polyethylenimine (PEI), a lipid anchor, a biocompatible hydrophilic polymer spacer, and a biodegradable linker which covalently links the branched PEI, the spacer and the cholesterol derived lipid anchor.
A biodegradable non-toxic cationic lipopolymer comprising a branched polyethylenimine (PEI) having an average molecular weight of 600 to 1200 Daltons, a lipid anchor, biocompatible hydrophilic polymer spacer, and a biodegradable linker which covalently links the branched PEI, the spacer and the cholesterol derived lipid anchor.
A biodegradable non-toxic cationic lipopolymer comprising a branched polyethylenimine (PEI) having an average molecular weight of 1800 to 25000 Daltons, a lipid anchor, biocompatible hydrophilic polymer spacer, and a biodegradable linker which covalently links the branched PEI, the spacer and the cholesterol derived lipid anchor.
A pharmaceutical composition comprising a bioactive agent and a biodegradable non-toxic cationic lipopolymer comprising a branched polyethylenimine (PEI), a lipid anchor, biocompatible hydrophilic polymer spacer, and a biodegradable linker which covalently links the branched PEI, the spacer and the cholesterol derived lipid anchor.
A method of deliverying a bioactive agent into a warm blooded animal, comprising administering a effective amount of the composition comprising a bioactive agent and a biodegradable non-toxic cationic lipopolymer comprising a branched polyethylenimine (PEI), a lipid anchor, biocompatible hydrophilic polymer spacer, and a biodegradable linker which covalently links the branched PEI, the spacer and the cholesterol derived lipid anchor to the animal under conditions wherein said composition enters said cells, and the bioactive agent of said composition is released.
Dependencies are inferred from the claim text.