Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof
OwnerLeonid A. Kozhemyakin, Andrew L. Kozhemyakininventors
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Abstract
The invention relates to new compositions and medical uses, such as anti-infectious pharmacology. The compositions include salts and compounds of GSSG including a nitrogenous base comprising one or more of DNA bases, nucleosides of DNA bases, nucleotides of DNA bases, RNA bases, nucleosides of RNA bases, nucleotides of RNA bases, inosine, nucleotides of inosine, and homologues, analogues and derivatives thereof. The invention is also directed to methods for treatment and prevention of infectious diseases such as viral hepatitis B and C, AIDS and herpes.
Claims66
A composition comprising an oxidized glutathione salt, at least one counterion of the oxidized glutathione comprising a nitrogenous base including one or more of DNA bases, nucleosides of DNA bases, nucleotides of DNA bases, RNA bases, nucleosides of RNA bases, nucleotides of RNA bases, inosine, nucleotides of inosine, and homologues, analogues and derivatives thereof.
A composition comprising an oxidized glutathione bonded to at least one phosphate.
A method of making an organic salt, comprising:
- providing a solution comprising glutathione in anionic form;
- oxidizing the glutathione;
- and
- adding a nitrogenous base to the solution, the base including one or more of DNA bases, nucleosides of DNA bases, nucleotides of DNA bases, RNA bases, nucleosides of RNA bases, nucleotides of RNA bases, inosine, nucleotides of inosine, and homologues, analogues and derivatives thereof.
A method of making an organic salt, comprising:
- providing a solution comprising oxidized glutathione in anionic form;
- and
- adding a nitrogenous base to the solution, the base including one or more of DNA bases, nucleosides of DNA bases, nucleotides of DNA bases, RNA bases, nucleosides of RNA bases, nucleotides of RNA bases, inosine, nucleotides of inosine, and homologues, analogues and derivatives thereof.
A method of making an oxidized glutathione derivative, comprising:
- reacting a glutamic acid or glutamate of oxidized glutathione or oxidized glutathione salt with phosphoric acid or a phosphoric acid derivative.
A method of treating an disease, comprising:
- introducing into a subject an effective amount of a composition to achieve a therapeutic effect, the composition comprising an oxidized glutathione salt and at least one counterion of the oxidized glutathione comprising a nitrogenous base.
A method for treating a subject in need treatment of a condition caused by replicative activity of viruses, bacteria or other infecting agents, comprising:
- introducing into the subject in need of such treatment a composition to obtain a therapeutic effect, the composition comprising an oxidized glutathione salt, and at least one counterion of the oxidized glutathione comprising a nitrogenous base.
A method for treating a subject, comprising:
- introducing into the subject in need of such treatment a composition to obtain a cell-protective effect, the composition comprising an oxidized glutathione salt, and at least one counterion of the oxidized glutathione comprising a nitrogenous base.
Dependencies are inferred from the claim text.