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US 2003/0073091 A1Published application
Use of generic oligonucleotide microchips to detect protein-nucleic acid interactions
AssigneeThe University of Chicago
InventorsAlexander S. Krylov, Andrei Mirzabekov, Dmitry V. Prokopenko, Olga A. Zasedateleva
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Abstract
Nucleic acids or proteins immobilized in a gel pad are interacting with a protein and the nucleic acid-protein and protein-protein interactions are characterized and measured. Large-scale, parallel measurements of these interactions can be examined to provide a powerful tool in elucidating interactions between proteins and nucleic acids.
Claims23
A method for characterizing a nucleic acid-protein interaction comprising:
- (a) immobilizing a nucleic acid or a protein on a solid support;
- (b) contacting the nucleic acid and the protein under conditions which allow the nucleic acid and the protein to interact;
- and
- (c) measuring the strength of the nucleic acid-protein interaction.
1 more element
A method for characterizing a protein-protein interaction comprising:
- (a) immobilizing a protein on a solid support;
- (b) contacting the protein with a second protein under conditions which allow the proteins to interact;
- and
- (c) measuring the strength of the protein-protein interaction.
1 more element
Dependencies are inferred from the claim text.