Sampling article for determining quantitative and qualitative drug transfer to skin
OwnerJerome James Workman JR., Corey Thomas Cunningham +1inventors
InventorsJerome James Workman JR., Corey Thomas Cunningham, Terry William Adler
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Abstract
An article for measuring external drug transfer to skin surfaces includes a high molecular weight polyolefin substrate film and a skin-adhering element attached to the polyolefin substrate film. The substrate film has a texture that simulates skin roughness and topography on the surface facing a drug delivery medium. The substrate film, skin-adhering element, and all other components of, or in contact with, the sampling article provide minimum interference with chemical analysis of the active drug being measured.
Claims35
An article for measuring external drug transfer to skin surfaces, comprising:
- a polyolefin substrate film including at least one of the group consisting of polyethylene and polypropylene, the film having a weight-average molecular weight between about 3 and about 6 kilograms/mole;
- and
- a skin-adhering element attached to the polyolefin substrate film, wherein the article is free of aromatic organic compounds, polyenes, acrylates, esters, waxes, dimethicones and silicone-based compounds.
An article for measuring external drug transfer to skin surfaces, comprising:
- a polytetrafluoroethylene substrate film having a weight-average molecular weight between about 35 and about 65 kilograms/mole;
- and
- a skin-adhering element attached to the polytetrafluoroethylene substrate film, wherein the article is free of aromatic organic compounds, polyenes, acrylates, esters, waxes, dimethicones and silicone-based compounds.
An article for measuring external drug transfer to skin surfaces, comprising:
- a substrate including at least one of the group consisting of metallic foil film, metallized film, poly(methyl methacrylate), poly(vinyl alcohol), poly(ethylene oxide), poly(ethylene terephthalate), polycaprolactam, poly(hexamethylene adipamide), poly(α-1,6-D-glucose), polydimethylsiloxanes, and poly(cis-1,4-isoprene);
- and
- a skin-adhering element attached to the substrate, wherein the article is free of aromatic organic compounds, polyenes, acrylates, esters, waxes, dimethicones and silicone-based compounds.
Dependencies are inferred from the claim text.