Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
AssigneeSchering Corporation
InventorsTeddy Kosoglou, Rudyard J. Ress, John T. Strony, Enrico P. Veltri, William Hauer
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Abstract
The present invention provides compositions, therapeutic combinations and methods including: (a) at least one sterol absorption inhibitor and (b) at least one cardiovascular agent different from the sterol absorption inhibitor, which can be useful for treating vascular conditions, obesity, diabetes and lowering plasma levels of sterols.
Claims49
A composition comprising:
- (a) at least one sterol absorption inhibitor or pharmaceutically acceptable salt or solvate thereof or prodrug of the at least one sterol absorption inhibitor or of the salt or solvate thereof;
- and
- (b) at least one cardiovascular agent for treating vascular conditions which is different from the at least one sterol absorption inhibitor.
A method of treating or preventing vascular conditions, diabetes, obesity or lowering a concentration of a sterol in plasma of a mammal, comprising the step of administering to a mammal in need of such treatment:
- (a) an effective amount of at least one sterol absorption inhibitor or pharmaceutically acceptable salt or solvate thereof or prodrug of the at least one sterol absorption inhibitor or of the salt or solvate thereof;
- and
- (b) an effective amount of at least one cardiovascular agent which is different from the sterol absorption inhibitor.
A therapeutic combination comprising:
- (a) a first amount of at least one sterol absorption inhibitor or pharmaceutically acceptable salt or solvate thereof or prodrug of the at least one sterol absorption inhibitor or of the salt or solvate thereof;
- and
- (b) a second amount of at least one cardiovascular agent different from the at least one sterol absorption inhibitor.
- wherein the first amount and the second amount together comprise a therapeutically effective amount for the treatment or prevention of a vascular condition, obesity, diabetes or lowering a concentration of a sterol in plasma of a mammal.
Dependencies are inferred from the claim text.