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US 2003/0068630 A1Published application
Protein-protein interactions
AssigneeMyriad Genetics, Inc.
InventorsDaniel M. Cimbora, Karen Heichman, Paul L. Bartel
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AssigneeMyriad Genetics, Inc.
InventorsDaniel M. Cimbora, Karen Heichman, Paul L. Bartel
Estimating the term…
The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
An isolated protein complex comprising two proteins, the protein complex selected from the group consisting of:
An isolated nucleic acid encoding a protein comprising an amino acid sequence set forth in SEQ ID NO:
An isolated nucleic acid encoding a protein comprising an amino acid sequence which is at least 70% identical to the amino acid sequence set forth in SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence which is at least 60% identical to nucleotides 1-1872 of SEQ ID NO:
An isolated nucleic acid sequence comprising a nucleotide sequence set forth in SEQ ID NO:
An isolated nucleic acid comprising a contiguous span of at least 17 nucleotides of the nucleotide sequence set forth in SEQ ID NO:
An isolated nucleic acid comprising at least 21 nucleotides that encodes a contiguous span of at least 7 amino acids of the amino acid sequence set forth in SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence set forth in SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence that is at least 70% identical to the amino acid sequence set forth in SEQ ID NO:
An isolated polypeptide comprising a contiguous span of at least 8 amino acids of the amino acid sequence set forth in SEQ ID NO:
An isolated polypeptide comprising an amino acid sequence of from 4 to 30 amino acids that is at least 75% identical to a contiguous span of amino acids of the amino acid sequence set forth in SEQ ID NO:
A method for making an isolated polypeptide comprising an amino acid sequence set forth in SEQ ID NO:
Dependencies are inferred from the claim text.