TNF receptor 2 related protein variant
OwnerPreeti G. Lal, Bridget A. Warreninventors
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Abstract
The invention provides a cDNA which encodes a TNFR2PV. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cancer and immune disorders, particularly cancer of the prostate, ovary, breast, and brain, or an inflammatory disorder, including rheumatoid arthritis, asthma, and ulcerative colitis. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
Claims22
An isolated cDNA comprising a nucleic acid sequence encoding a protein having the amino acid sequence of SEQ ID NO:1, or the complement of the cDNA.
An isolated cDNA comprising a nucleic acid sequence selected from:
- a) SEQ ID NO:2 or the complement thereof;
- b) a fragment of SEQ ID NO:2, selected from SEQ ID NOs:7-9, or the complement thereof;
- and
- c) a variant of SEQ ID NO:2 having at least 85% identity to SEQ ID NO:2, or the complement thereof.
An isolated cDNA comprising a nucleic acid of SEQ ID NO:2
Dependencies are inferred from the claim text.