Sequential drug delivery systems
OwnerS. Indiran Pather, John Hontz +1inventors
InventorsS. Indiran Pather, John Hontz, John M. Siebert
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Abstract
The invention relates to methods and composition for improving absorption and dissolution of active ingredients of drugs. The invention provides a method of administration of an active ingredient to a mammal through a transmucosal route that includes delivering the active ingredient to a desired site in a body of the mammal, and, sequentially, at the desired site, promoting dissolution and absorption of the active ingredient. In a preferred embodiment, the pH of the localized environment of the active ingredient is sequentially modified to promote dissolution and absorption.
Claims46
A method of administration of an active ingredient to a mammal through a transmucosal route, said method comprising:
- a. delivering said active ingredient to a desired site in a body of said mammal;
- and, sequentially, at said desired site,
- b. promoting dissolution of said active ingredient,
- c. promoting absorption of said active ingredient.
A method for administering an active ingredient via a transmucosal route in a mammal, comprising administering said active ingredient in a dosage form with a first pH-adjusting substance and a second pH-adjusting substance so that said first pH-adjusting substance attains peak activity in the localized environment of the active ingredient before said second pH-adjusting substance attains peak activity in the localized environment of the active ingredient, whereby the localized environment of the active ingredient attains a first pH and then a second pH, said first pH promoting dissolution of said active ingredient and said second pH promoting absorption of said active ingredient.
A pharmaceutical composition comprising an active ingredient in a dosage form comprising a first portion, a second portion and means for sequential release of said first portion and said second portion at desired site;
- said first portion including one or more first substances that promote dissolution of said active ingredient;
- said second portion including one or more second substances that promote absorption of said active ingredient.
Dependencies are inferred from the claim text.