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US 2003/0068321 A1Published application
Methods of effecting neuronal activity
AssigneeGuilford Pharmaceuticals Inc.
InventorsGregory S. Hamilton, Ling Wei, Joseph P. Steiner
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Abstract
This invention is related to methods of effecting neuronal activity with non-immunosuppressive neurotrophic low molecular weight, small molecule cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins. The methods of this invention are useful in the stimulation of damaged neurons, promotion of neuronal regeneration, prevention of neurodegeneration, and treatment of neurological disorders.
Claims16
A method of effecting a neuronal activity in an animal, comprising:
- administering to the animal an effective amount of a non-immunosuppressive neurotrophic compound having an affinity for a cyclophilin-type immunophilin, wherein the immunophilin exhibits rotamase activity and the neurotrophic compound inhibits the rotamase activity of the immunophilin.
Dependencies are inferred from the claim text.