Metal-carborane complexes for radioimaging and radiotherapy and methods for their preparation
AssigneeMcMaster University
InventorsJohn F. Valliant, Pierre Morel, Paul Schaffer, Oyebola O. Sogbein
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Abstract
The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [M(CO)3(Xm)3](1+3m), wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]2− and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.
Claims20
A method for preparing technetium- and rhenium-carborane complexes comprising reacting salt of the formula:
- [M(CO)3(Xm)3](1+3m) wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]2−and functional derivatives thereof.
A metal-carborane complex comprising the formula [M(CO)3(η5-7,8-C2B9H10)]−, wherein M is a radioisotope of technetium, and functional derivatives thereof.
A metal-carborane complex comprising the formula [M(CO)3(η5-7,9-C2B9H10)]−, wherein M is selected from a radioisotope of technetium and rhenium, and functional derivatives thereof.
A metal-carborane complex having the formula [M(CO)3(η5-7-R-7,8-C2B9H10)]−, [M(CO)3(η5-8-R′-7,8-C2B9H10)]− or [M(CO)3(η5-7-R,8-R′-7,8-C2B9H10)]−, wherein M is selected from a radioisotope of technetium and rhenium and R and R′ are independently selected from the group consisting of (CH2)nCO2H, NH2 and NH-NH2, wherein n is 0-50.
A metal-carborane complex having the formula [M(CO)3(η5-7-R-7,9-C2B9H10)]−, [M(CO)3(η5-9-R′-7,9-C2B9H10)]− or [M(CO)3(η5-7-R,9-R′-7,9-C2B9H10)]−, wherein M is selected from a radioisotope of technetium and rhenium and R and R′ are independently selected from (CH2)nCO2H, NH2 and NH-NH2, wherein n is 0-50.
Dependencies are inferred from the claim text.