Bovine cells expressing adenovirus essential functions for propagation of recombinant adenoviral vectors
OwnerSuresh Kumar Tikoo, Lorne A. Babiuk +1inventors
InventorsSuresh Kumar Tikoo, Lorne A. Babiuk, Police Seshidhar Reddy
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Abstract
The invention provides cell lines capable of supporting the replication of a defective recombinant virus vector. In one aspect, bovine cell lines expressing adenovirus E1 functions are provided. The cell lines are useful for the propagation of adenovirus vectors with mutations and/or deletions in E1 and other essential regions of the adenovirus genome.
Claims37
A bovine cell that expresses a function essential for replication of an adenovirus, wherein the cell is permissive for the replication of a recombinant adenovirus vector having a mutation in a region of its genome corresponding to the essential function provided by the host cell.
A cell that expresses a function essential for replication of a particular type or species of adenovirus, wherein the cell is permissive for the replication of a recombinant adenovirus vector of a different type or species, wherein the recombinant adenovirus vector has a mutation in a region of its genome corresponding to the essential function provided by the host cell.
Dependencies are inferred from the claim text.