Antigen presenting cells, a process for preparing the same and their use as cellular vaccines
AssigneeI.D.M. Immuno-Designed
InventorsMohamed Chokri, Jacques Bartholeyns, Jean-Loup Romet-Lemonne
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Abstract
The invention relates to monocytes derived antigen presenting cells (MD-APCs) characterized in that they have the following properties: they present on their surface: antigen CD14 and CD64 with a mean intensity of about 5 to about 200; antigen CD80 and CD86 with a mean intensity of about 20 to about 200; antigen CD40 and mannose receptor with a mean intensity of 50 to 500; they are substantially devoid of the surface antigens CD1a and CD1c; they present a phagocytosis property; and they have the property of stimulating the proliferation of allogenic lymphocytes.
Claims21
A method of clinically treating a patient, comprising:
- administering to said patient an effective amount of monocyte derived antigen presenting cells (MD-APCs) which present the following properties:
- the presence on the MD-APC cell surface of surface antigens CD80 and CD86, and
- the presence on the MD-APC cell surface of surface antigens CD40 and mannose receptor.
A method of clinically treating a patient, comprising:
- administering to said patient an effective amount monocyte derived cells (MD-APCs) which present the following properties:
- a higher phagocytic capacity than mature dendritic cells, and
- a greater capability of stimulating proliferation of allogenic lymphocytes relative to standard macrophages.
A method of clinically treating a patient, comprising:
- administering to said patient an effective amount monocyte derived cells (MD-APCs) which present the following properties:
- the presence on the MD-APC cell surface of surface antigens CD80 and CD 86,
- the presence on the MD-APC cell surface of surface antigens CD40 and mannose receptor, and the presence on the MD-APC cell surface of surface antigen CD 14.
The method according to claim 18, wherein said mononuclear cells present IL 13 receptors on their surface.
Dependencies are inferred from the claim text.