Membrane for use in guided tissue regeneration
AssigneeEd. Geistlich Soehne AG fuer Chemische Industrie
InventorsPeter Geistlich, Zdenek Eckmayer, Lothar Schlosser
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Abstract
The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.
Claims22
A multi-layer membrane suitable for use in vivo in the reconstruction of bone or cartilage tissue, said membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture.
A membrane as claimed in any preceding claim in which the matrix layer is impregnated with chondrocytes isolated from articular cartilage, periosteum, periocardium or mesenchymal stem cells from bone marrow.
A membrane as claimed in any preceding claim in which the matrix layer and/or barrier layers are impregnated with a glycosaminoglycan.
A membrane as claimed in any preceding claim in which the matrix and barrier layers are substantially free from proteoglycans.
A membrane as claimed in any preceding claim in which the matrix and/or barrier layers further comprise chondronectin, laminin, fibronectin, calcium alginate, anchorin II, growth factors or bone morphogenetic factors.
Dependencies are inferred from the claim text.