Novel substituted calix (4) pyrroles and process for the synthesis of calix (4) pyrroles over molecular sieve catalysts
AssigneeCouncil of Scientific and Industrial Research
InventorsKondapuram Vijaya Raghavan, Shivanand Janardan Kulkarni, Motkuri Radha Kishan, Nagabandi Srinivas
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Abstract
The present invention relates to novel calix pyrroles and a process for synthesis of calix (4) pyrroles by reacting pyrrole with cyclic or acyclic ketones in dichloro methane (DCM) solvent over molecular sieve catalysts which provides an eco-friendly, more economical and selective heterogeneous method.
Claims29
Novel compounds of substituted calix(4) pyrroles namely tetraspiro cycloheptyl calix (4) pyrrole , tetraspiro cyclooctyl calix (4) pyrrole and tetraspiro (2-methyl cyclohexyl) calix(4) pyrrole as shown in structural formulae 6a, 7a and 8a of the accompanying drawings, for use in many industrial applications particularly in biological applications.
A method for preparing substituted calix (4) pyrroles, said method comprising reacting a pyrrole with a acyclic and cyclic ketones over a mesoporus molecular sieve solid acid catalyst in presence of a solvent, at reflux temperature of about 100° C. for period ranging from 10 to 72 hours, recovering the solid products by filtration, washing with deionized water and drying in air and calcined at 773K in air.
A method for preparing calix (4) pyrroles or tetraspiro calix (4) pyrroles, said method comprising mixing a pyrrole with a acyclic or cyclic ketones over a molecular sieve solid acid catalyst and subjecting the mixture to microwave radiation for 3 to 10 minutes and optionally, refluxing using a solvent for extracting the compounds.
Dependencies are inferred from the claim text.