Solid phase synthesis
AssigneeQuiatech AB
InventorsMarek Kwiatkowski, Mats Nilsson, Ulf Landegren
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Abstract
The present invention relates to a support system for solid phase synthesis of oligomers, such as oligonucleotides, wherein the starting compound is bound to the support via a disiloxyl linkage. Furthermore, the invention relates to a method for synthesis of oligonucleotides on a solid support. The support system comprises a stable disiloxyl linkage providing high nucleoside loadings to the support and the method allows convenient non-laborious oligomer synthesis.
Claims10
A support system, for solid phase synthesis of oligomers, comprising a support, a linker and a starting compound of the oligomer, characterized in that the starting compound of the oligomer is bound to the support via a disiloxyl linkage.
A support system according to any one of the above claims, characterized in that R1 is a trityl, monomethoxy trityl, dimethoxytrityl, pixyl or other higher alkoxy-substituted trityl-protecting groups, and B is adenine, guanine, cytosine, uracil, thymine, or inosine.
A support system according to any one of the above claims, characterized in that R3, R4, R5, R6 are isopropyl.
Dependencies are inferred from the claim text.