Acetate-lactate buffering vaginal gel and for method of making same and treating bacterial vaginosis
OwnerCalvin Hanna, Lindley A Catesinventors
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Abstract
A composition of matter comprising a pH buffering system comprising a combination of lactic acid and related base salt that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina. The composition my include a gel form, and also contain acetic acid as well as polyethylene glycol, glycerol and oxyquinoline.
Claims36
A composition of matter comprising a pH buffering system comprising a combination of lactic acid and hydrogen-accepting substance that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina.
A composition of matter comprising a dual pH buffering system comprising a combination of lactic acid and hydrogen-accepting substance that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina, wherein:
- a. said lactic acid comprises lactic acid of about 2.0% v/v;
- b. said substance comprises potassium hydroxide solution (2N) of about 2.4% v/v;
- c. said polyethylene glycol comprises polyethylene glycol 4500 of about 62.0% v/v;
- d. said glycerol comprises about 15.0% v/v;
- e. said oxyquinoline sulfate comprises about 0.025% v/v;
- and
- f. the remainder comprises water q.s. to 100%.
A method of making a composition of matter comprising a dual pH buffering system comprising a combination of lactic acid, a second acid and hydrogen-accepting substance that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina, said method of making comprising the steps of mixing said acids and substance in solution, then applying said mixture to the vaginal surface.
A method of making a composition of matter comprising a dual pH buffering system comprising a combination of lactic acid, a second acid and hydrogen-accepting substance that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina, said method of making comprising the steps of:
- a. warming about 403 grams of polyethylene glycol 4500 to about 50° C. (ultimately to be about 62.0% v/v);
- b. mixing therein about 97.5 grams of glycerol, about 13.0 grams of lactic acid, about 5.85 grams of acetic acid, about 16.0 grams of potassium hydroxide solution, and about 50.0 grams of water, and stir at about 40° C. until fully mixed;
- and
- c. cooling to about 21° C. and adding about 51 grams of water.
A method of using a composition of matter comprising a dual pH buffering system comprising a combination of lactic acid, a second acid and hydrogen-accepting substance that occur naturally in the human female body that, when applied to the surface of the vagina, maintains the pH level thereon at approximately the pH level of a healthy vagina, said method of using comprising the steps of contacting the vaginal surface with a therapeutically effective amount of said composition.
Dependencies are inferred from the claim text.