Pharmaceutical formulation comprising glycine as a stabilizer

A method for preventing or treating a disorder associated with the secretion of gastric acid in a person requiring the same comprising administering to the person an aqueous pharmaceutical formulation suitable for intravenous injection comprising glycine and a compound of formula (I) or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier;

• wherein the compound of formula (I) is:
• 15
• or a stereoisomer thereof;
• wherein R1 and R2 are each independently a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, a halogenated lower alkyl, a lower alkoxycarbonyl or carboxyl group;
• X is —O—, —S— or ═N—R3, wherein R3 is a hydrogen atom, a lower alkyl, phenyl, benzyl or lower alkoxycarbonyl group;
• and
• Z is:
• 1. —O(CH2)p—O—R4
• wherein p is an integer of 1 to 3 and R4 is hydrogen atom or a lower alkyl, aryl or aralkyl group,
• 2. —O—(CH2)q—R5
• wherein q is an integer of 1 to 3 and R is a halogen atom or an alkoxycarbonyl, aryl or heteroaryl group,
• 3. —O—(CH2)r—O—(CH2)s—O—R6
• wherein r and s are each independently an integer of 1 to 5 and R6 is a hydrogen atom or a lower alkyl group,
• 16
• 7. —S(O)t—A
• wherein t is an integer of 0 to 2, and A is a lower alkyl, alkoxycarbonylmethyl, pyridyl, furyl,
• 17
• wherein P is —NH—, —O— or —S—;
• R7 is hydrogen or lower alkyl;
• and w is an integer of 0or 3;
• 8. —N(R8)—CH2—C6H5
• wherein R8 is an acetoxy or lower alkyl group;
• 9. —OR9
• wherein R9 is a hydrogen atom, a lower alkyl or aryl group;
• n is an integer of 0 to 2;
• m is an integer of 2 to 10, and J and K are each independently a hydrogen atom or a lower alkyl group;
• with the proviso that when Z is a group falling under the above category (9), then R9 is a lower alkyl group and m is an integer of 3 to 10.