Combinations with statin and aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use

A compound of formula I

• 26
• wherein:
• R1 is phenyl or heteroaryl, wherein the aromatic or heteroaromatic ring is unsubstituted, or is mono- to trisubstituted by fluorine, chlorine, bromine, iodine, —OH, —CF3, —NO2, —CN, —(C1-C8)-alkoxy, —(C1-C8)-alkyl, —NH2, —NH—R9, —N(R9)R10, —CHO, —COOH, —COOR11, —(C═O)—R12, —(C1-C6)-alkyl-OH, —(C1-C6)-alkyl(—OH)-phenyl, —(C1-C6)-alkyl-CF3, —(C1-C6)-alkyl-NO2, —(C1-C6)-alkyl-CN, —(C1-C6)-alkyl-NH2, —(C1-C6)-alkyl-NH—R9, —(C1-C6)-alkyl-N(R9)R10, —(C1-C6)-alkyl-CHO, —(C1-C6)-alkyl-COOH, —(C1-C6)-alkyl-COOR11, —(C1-C6)-alkyl-(C═O)—R12, —O—(C1-C6)-alky-OH, —O—(C1-C6)—alkyl-CF3, —O—(C1-C6)-alkyl-NO2, —O—(C1-C6)-alkyl-CN, —O—(C1-C6)-alkyl-NH2, —O—(C1-C6)-alkyl-NH—R9, —O—(C1-C6)-alkyl-N(R9)R10, —O—(C1-C6)—alkyl-CHO, —O—(C1-C6)-alkyl-COOH, —O—(C1-C6)-alkyl-COOR11, —O—(C1-C6)-alkyl-(C═O)—R12, —N—SO3H, —SO2—CH3, —O—(C1-C6)-alkyl-O—(C1-C6)—alkyl-phenyl, —(C1-C6)-alkylthio or pyridyl, wherein one or more hydrogen(s) in the alkyl radicals may be optionally replaced by fluorine, and wherein phenyl and pyridyl may be unsubstituted or monosubstituted by methyl, methoxy or halogen,
• R2 is H, —OH, —CH2OH, —OMe, CHO, or —NH2;
• R3 is a sugar residue, disugar residue, trisugar residue, tetrasugar residue, wherein the sugar residue, disugar residue, trisugar residue or tetrasugar residue was unsubstituted or was mono- or polysubstituted by a sugar protective group, HO—SO2—, or (HO)2—PO—;
• R4 is H, methyl, F, or —OMe;
• R9 to R12 each independently of one another is H or —(C1-C8)-alkyl;
• Z is —NH—(C0-C16)-alkyl-C═O—, —O—(C0-C16)-alkyl-C═O—, —(C═O)m—(C1-C16)—alkyl-(C═O)n, an amino acid residue, a diamino acid residue, wherein the amino acid residue or diamino acid residue is unsubstituted, or mono- or polysubstituted by an amino acid protective group, or a covalent bond;
• n is 0 or 1;
• m is 0 or 1;
• or a pharmaceutically tolerated salt, or a physiologically functional derivative thereof.