Agents and crystals for improving excretory potency of urinary bladder
OwnerYuji Ishihara, Takayuki Doi +2inventors
InventorsYuji Ishihara, Takayuki Doi, Hiroshi Nagabukuro, Yuji Ishichi
Life of this patent
Estimating the term…
Abstract
Agents for improving potentcy of the urinary bladder which comprises an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action. Particularly, crystals of a tricyclic, condensed, heterocyclic derivative are provided, which possess an excellent action to inhibit acetylcholine esterase and an action to improve the excretory potency of urinary bladder. As an example, crystals of of 8-[3-[1-[(3-fluorophenyl)-methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one or a salt thereof and pharmaceutical compositions containing them are disclosed.
Claims34
A pharmaceutical composition for improving excretory potency of the urinary bladder which comprises a non-carbamate amine compound having an acetylcholinesterase-inhibiting action together with a pharmaceutically acceptable carrier.
A pharmaceutical composition for improving excretory potency of the urinary bladder which comprises a combination of an α-blocker and a non-carbamate amine compound having an acetylcholinesterase-inhibiting action.
A process for producing a pharmaceutical composition for improving excretory potency of a urinary bladder comprising combining a non-carbamate amine compound having an acetylcholinesterase-inhibiting action and a pharmaceutically acceptable carrier.
A method for improving the excretory potency of a urinary bladder which comprises administering a therepeutically effective amount of an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action to a patient in need thereof.
Crystals of 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one or a salt thereof.
A pharmaceutical composition for improving the excretory potency of urinary bladder, which comprises crystals of 8-[3-[1-[(3-fluorophenyl)methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one or a salt thereof and an α-blocker.
Dependencies are inferred from the claim text.