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US 2002/0177583 A1Published application
Methods and compositions for the treatment of human and animal cancers
AssigneeZoltan Laboratories LLC
InventorZoltan Kiss
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AssigneeZoltan Laboratories LLC
InventorZoltan Kiss
Estimating the term…
Methods and compositions for altering the viability of cells, particularly cancers in animals and humans are disclosed. The compositions of the present invention are formed from a set of components comprising one or more of the following: a dithiocarbonyl, preferably dithiocarbamate, compound; a divalent metal ion; a modulator of cellular glutathione levels; and an inhibitor of the phosphorylation of choline. The compositions described herein induce a relatively selective and rapid effect on the viability of cancer cells by inducing a mixture of apoptotic and necrotic cell death, with the dominant pathway being apoptosis. Particularly preferred active compositions comprise all four components, although combinations of fewer components can be fully effective in certain tumors.
A composition capable of inducing apoptosis or necrosis in cancer cells, comprising:
A method of identifying a therapeutic composition for treating one or more cancers, comprising the steps of:
A composition capable of inducing apoptosis or necrosis in one or more cancer cells, comprising:
The composition of claim 27, wherein the dithiocarbonyl is PDC.
A composition capable of inducing apoptosis or necrosis in one or more cancer cells, comprising:
A composition capable of inducing apoptosis or necrosis in one or more cancer cells, comprising:
A composition capable of inducing apoptosis or necrosis in one or more cancer cells, comprising:
Dependencies are inferred from the claim text.