Extended release formulation of water-soluble drugs
OwnerLarry Augsburger, John A. Bonck JR. +1inventors
InventorsLarry Augsburger, John A. Bonck JR., Albert W. Brzeczko
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Abstract
A novel process for producing extended release formulation of a water-soluble drug comprising the steps of making a “modified drug” comprising a hot-melt granulation of the drug with soluble or dispersible polymeric material of a suitable molecular weight and melting point, coating portions of the modified drug to different thicknesses or weights so as to produce subbatches, and blending the subbatches to achieve a specific drug release profile.
Claims8
A process for producing extended release formulation of a water-soluble drug comprising the steps of making a “modified drug” comprising a hot-melt granulation of the drug with soluble or dispersible polymeric material of a suitable molecular weight and melting point, coating portions of the modified drug to different thicknesses or weights so as to produce subbatches, and blending the subbatches to achieve a specified drug release profile.
An extended release drug comprising a granulation of a water soluble pharmacophore coated with a suitable coating material so as to produce granules of a modified drug, wherein there are at least two types of granules of the modified drug, said types distinguished by the thickness or weight of said coating material.
Dependencies are inferred from the claim text.