Exotoxin-ligand
OwnerHans E. Maschke, Veit Ottoinventors
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Abstract
The present invention relates to a ligand for bacterial toxins, particularly entero- or exotoxins of gram-positive bacteria, which is capable of selective interaction with a structure containing an amino acid sequence conserved in the bacterial toxins. The invention also relates to an adsorbent that exhibits the ligand bound to a matrix, an adsorption device for reducing the concentration of bacterial toxins in blood or blood plasma as well as a pharmaceutical composition, which contains the ligands, and which is suitable in particular for the treatment and/or prevention of gram-positive sepsis.
Claims34
Ligand for bacterial toxins, which is capable of selective interaction with the β-sheet-hinge-α-helix structure of the superantigens.
Use of the adsorbent according to any one of claims 6 to 19 for the purification of bacterial toxins.
Dependencies are inferred from the claim text.