Tuberculosis vaccine
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorsStefan H.E. Kaufmann, Jurgen Hess
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Abstract
The present invention relates to novel recombinant vaccines providing protective immunity against tuberculosis. Further, the present invention refers to novel recombinant nucleic acid molecules, vectors containing said nucleic acid molecules, cells transformed with said nucleic acid molecules and polypeptides encoded by said nucleic acid molecules.
Claims31
A recombinant nucleic acid molecule encoding a fusion polypeptide comprising (a) at least one domain from a Mycobacterium polypeptide, wherein said domain is capable of eliciting an immune response in a mammal, and (b) a phagolysosomal escape domain.
A recombinant Mycobacterium bovis cell, which comprises at least one recombinant nucleic acid molecule encoding a fusion polypeptide comprising (a) at least one domain capable of eliciting an immune response in a mammal and (b) a phagolysosomal escape domain.
A recombinant Mycobacterium bovis cell which comprises at least one recombinant nucleic acid molecule encoding a phagolysosomal escape peptide or polypeptide.
Dependencies are inferred from the claim text.