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AssigneeThe United States of America as represented by the Secretary of the Army
InventorsJames L. Meyerhoff, Debra L. Yourick, Michael L. Koenig
Estimating the term…
Methods of preventing, treating, or both preventing and treating CNS injury, disease, neurotoxicity or memory deficit in a subject by the administration of at least one lipoic acid compound to the subject are disclosed. Examples of CNS injuries or disease include traumatic brain injury (TBI), posttraumatic epilepsy (PTE), stroke, cerebral ischemia, neurodegenerative diseases of the brain such as Parkinson's disease, Dementia Pugilistica, Huntington's disease and Alzheimer's disease, brain injuries secondary to seizures which are induced by radiation, exposure to ionizing or iron plasma, nerve agents, cyanide, toxic concentrations of oxygen, neurotoxicity due to CNS malaria or treatment with anti-malaria agents, and other CNS traumas. Examples of lipoic acid compounds include alpha-lipoic acid (ALA), dihydrolipoic acid (DHLA), 2-(N,N-dimethylamine) ethylamido lipoate-HCL (LA-plus), the oxidized or reduced R- or S-isomers thereof, the metabolites of alpha-lipoic acid such as 6,8-bisnorlipoic acid and tetranorlipoic acid and analogs thereof. Also disclosed are pharmaceutical compositions and kits comprising at least one lipoic acid compound.
A method of treating a subject suffering from a central nervous system injury or disease comprising administering to the subject a composition comprising a therapeutically effective amount of at least one lipoic acid compound.
A method of preventing or inhibiting a central nervous system injury or disease in a subject comprising administering to the subject a composition comprising a therapeutically effective amount of at least one lipoic acid compound.
A method of preventing, inhibiting or treating a central nervous system injury or disease, neurotoxicity or memory deficit in a subject comprising administering to the subject a composition comprising a therapeutically effective amount of at least one lipoic acid compound.
A pharmaceutical composition for preventing, inhibiting, or treating a central nervous system injury, disease or neurotoxicity in a subject comprising a therapeutically effective amount of at least one lipoic acid compound and a pharmaceutically acceptable excipient.
A kit comprising a composition comprising a therapeutically effective amount of at least one lipoic acid compound.
Dependencies are inferred from the claim text.