Compositions and methods for the therapy and diagnosis of colon cancer
AssigneeCorixa Corporation
InventorsYuqiu Jiang, Susan L. Harlocker, Heather Secrist
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
Claims17
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- (a) sequences provided in SEQ ID NO:1-2234;
- (b) complements of the sequences provided in SEQ ID NO:1-2234;
- (c) sequences consisting of at least 20 contiguous residues of a sequence provided in SEQ ID NO:1-2234;
- (d) sequences that hybridize to a sequence provided in SEQ ID NO:1-2234, under moderately stringent conditions;
- (e) sequences having at least 75% identity to a sequence of SEQ ID NO:1-2234;
- (f) sequences having at least 90% identity to a sequence of SEQ ID NO:1-2234;and (g) degenerate variants of a sequence provided in SEQ ID NO:1-2234.
An oligonucleotide that hybridizes to a sequence recited in SEQ ID NO:1-2234 under moderately stringent conditions.
Dependencies are inferred from the claim text.