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US 2002/0177551 A1Published application
Compositions and methods for treatment of neoplastic disease
OwnerDavid S. Termaninventor
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OwnerDavid S. Termaninventor
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The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides, nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are tumoricidal T cells and NKT cells devoid of inhitory receptors or inhibitory signaling motifs which are hyperresponsive to the the above compositions and lipid-based tumor associated antigens that can be administered for adoptive immunotherapy of cancer and infectious diseases.
A mammalian cell receptor useful in the treatment of cancer which binds tumor associated lipids wherein said binding induces anergy or apoptosis in said T cells and antigen presenting cells.
A mammalian cell useful in the treatment of cancer in a mammal wherein the receptor which binds tumor associated lipids and induces cellular inactivation or death is deleted or functionally deactivated.
A method for producing a tumoricidal immunocyte population in vivo in a mammal said method comprising allowing tumor associated lipids to contact immunocytes in which receptors for immunosuppressive fatty acids, ceramides, glycolipids, sphingolipids, glycosphingolipids, phosphosphingolipids, gangliosides, sialylated glycans, lipopeptides and proteoglycolipids. are inactivated or deleted.
A method for producing a tumoricical immunocyte population ex vivo in a mammal, said method comprising:
A method for producing a tumoricical antigen presenting cell population ex vivo in a mammal, said method comprising:
A method for producing a tumoricical T cell population ex vivo in a mammal, said method comprising:
A method of treating cancer in a mammal by administration of a lipid binding molecule which binds immunosuppressive tumor associated lipids in vivo.
A construct useful in the treatment of cancer comprising a superantigen nucleotide inserted into a virus.
A mammalian T cell useful in the treatment of cancer wherein an adaptor protein which inhibits T cell activation by tumor associated antigens is deleted or functionally deactivated.
A method for producing a tumoricidal T cell population in vivo in a mammal said method comprising allowing a tumor associated antigen and to contact immunocytes in which adaptor proteins which inhibit T cell activation by tumor associated antigens are deleted or functionally deactivated.
A composition useful in the treatment of cancer comprising a lipid raft conjugated to a superantigen.
A method for producing a tumoricical T cell population ex vivo in a mammal, said method comprising:
A method for producing a tumoricical T cell population ex vivo in a mammal, said method comprising:
Dependencies are inferred from the claim text.