Semaphorin K1
AssigneeExelixis, Inc.
InventorsYuling Luo, Xiaomei Xu
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Abstract
The invention provides methods and compositions relating to semaphorin K1 (sema K1) polypeptides which regulate cellular guidance and physiology, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed sema K1 encoding nucleic acids or purified from human cells. The invention provides isolated sema K1 hybridization probes and primers capable of specifically hybridizing with the disclosed sema K1 genes, sema K1-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Claims9
An isolated polypeptide comprising at least one of:
- (a) SEQ ID NO:2,
- (b) at least 100 contiguous residues of SEQ ID NO:2,
- (c) at least 60 contiguous residues of SEQ ID NO:2, residues 340-634, and
- (d) at least 12 contiguous residues of SEQ ID NO:2, residues 481-634.
An isolated or recombinant nucleic acid comprising a strand of at least one of:
- (a) SEQ ID NO:1,
- (b) at least 300 contiguous nucleotides of SEQ ID NO:1,
- (c) at least 102 contiguous nucleotides of SEQ ID NO:1, nucleotides 1017-2498, and.
- (d) at least 36 contiguous nucleotides of SEQ ID NO:1, nucleotides 1441-2498.
Dependencies are inferred from the claim text.