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US 2002/0177548 A1Published application
Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
AssigneeTularik Inc.
InventorsSusan Schwendner, Pieter Timmermans, Jacqueline Walling
Life of this patent
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Abstract
Combination therapies are provided for the treatment of proliferative disorders which use a pentafluorobenzenesulfonamide of formula I and an antineoplastic agent such as gemcitabine or paclitaxel.
Claims25
A composition for the treatment of proliferative disorders, comprising an antineoplastic agent and a compound having the formula:
- 5
- and pharmaceutically acceptable salts thereof;
- wherein
- R is a member selected from the group consisting of hydrogen and substituted or unsubstituted (C1-C10)alkyl;
- and
- Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroary
3 more elements
A method for the treatment of a proliferative disorder, comprising administering to a subject in need of such treatment:
- i) a first amount of an antineoplastic agent;
- and
- ii) a second amount of a compound of formula:
- 9
- and pharmaceutically acceptable salts thereof;
- wherein
- R is a member selected from the group consisting of hydrogen and substituted or unsubstituted (C1-C10)alkyl;
- and
- Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
- wherein said first amount and said second amount, in combination, are effective to treat said proliferative disorder
7 more elements
Dependencies are inferred from the claim text.