Tissue engineering enhanced by the transfer of a growth factor gene
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsHenning Madry, Gordana Vunjak-Novakovic, Stephen B. Trippel, Lisa E. Freed, Robert Langer
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Abstract
Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissue site. If the matrix is biodegradable, the metabolic result may include resorption of the matrix and replacement with tissue synthesized at least in part by the transfected cells
Claims42
A method of assembling a tissue engineered construct, comprising:
- transfecting a plurality of mammalian cells with a gene for a growth factor
A tissue engineered construct, comprising:
- a mammalian cell transfected with a gene for a growth factor;
- and
- a biocompatible synthetic matrix.
A method of facilitating regeneration of cartilage, comprising:
- transfecting a chondrocyte with a gene for a growth factor;
- seeding the cell onto a biocompatible synthetic matrix;
- implanting the cell-seeded matrix into an in vivo site.
A transfection vector for a mammalian cell, comprising a gene for a growth factor.
A plurality of transfected cells comprising chondrocytes, wherein the chondrocytes are transfected with a gene for a protein.
Dependencies are inferred from the claim text.