Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
AssigneeSmithKline Beecham Corporation
InventorsColin Houston MacPhee, David Graham Tew, Christopher Donald Southan, Deirdre Mary Bernadette Hickey, Israel Simon Gloger, Geoffrey Mark Prouse Lawrence, Simon Quentyn John Rice
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Abstract
The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.
Claims24
The enzyme Lp-PLA2 in purified form
An enzyme fragment selected from SEQ.ID NOs:
- 1, 2, 3, 4, 10 and 11.
An isolated nucleic acid molecule encoding Lp-PLA2 or an antisense analogue thereof.
The use of an inhibitor of the enzyme Lp-PLA2 in therapy.
The use of an inhibitor of Lp-PLA2 in the treatment of atherosclerosis.
A method of diagnosis of a patients susceptibility to atherosclerosis which comprises taking a sample of blood from the patient and analyzing said sample for the presence of the enzyme Lp-PLA2.
A method of screening compounds to identify those compunds which inhibit the enzyme comprising contacting isolated enzyme Lp-PLA2 with a test compound and measuring the rate of turnover of an enzyme substrate as corpared with the rate of turnover in the absence of test compound.
Dependencies are inferred from the claim text.