Recombinant simian GPR3 receptor
OwnerYanbin Liang, David F. Woodward +1inventors
InventorsYanbin Liang, David F. Woodward, Chen Li
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Abstract
The invention provides recombinant materials for the production of the simian form of G-protein receptor 3 which differs in several aspects from the human counterpart. Compounds which interact with this receptor are useful in the treatment of glaucoma.
Claims24
An isolated nucleic acid molecule comprising a nucleotide sequence encoding simian GPR3 receptor having the amino acid sequence of SEQ. ID. NO:
- 2.
A nucleic acid molecule which comprises an expression system for simian GPR3 which expression system comprises a nucleotide sequence encoding SEQ. ID. No:
- 2 operably linked to control sequences for its expression.
An isolated single stranded nucleic acid having a nucleotide sequence complementary to SEQ ID NO:1 or a sufficient portion thereof to inhibit expression.
A single stranded nucleic acid which specifically forms a triplex with a nucleic acid duplex containing at least a portion of SEQ ID NO:
- 1 that is required for production of simian GPR3.
Antibodies immunospecific for simian GPR3 of SEQ. ID. NO:
- 2.
Dependencies are inferred from the claim text.