Method for the preparation of a coded chemical library

A synthesis particle as claimed in any one of the previous claims wherein different parts of the code are applied by single pulses of radiation.

A synthesis particle according to any one of the previous claims and being a resin bead comprising a synthesis support attached to a writing surface.

A pseudohomogeneous chemical library synthesis particle comprising writing and synthesis materials.

A coded chemical library which comprises a plurality of coded synthesis particles as claimed in any one of the previous claims, each particle having one or more members of the library attached to it.

A method for the preparation of a coded chemical library, which method comprises synthesising the chemical library on a plurality of synthesis particles and writing code on the synthesis particles using high-energy radiation during library synthesis, so as to provide the chemical library on a plurality of coded synthesis particles, and wherein the identity of library compounds associated with a synthesis particle is established by reference to its code.

The use of a pulsed laser to write a code onto a chemical library synthesis particle.

The use of a pulsed laser to write code onto a plurality of chemical synthesis particles in rapid succession.

A synthesis particle library or method for its preparation according to any one of the previous claims and wherein the code is provided by a series of dots which are marked at a fixed pitch on the synthesis particle(s).

The use of a robotic “pick and place” machine to manipulate synthesis particles according to any preceeding claim.