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US 2002/0177158 A1Published application
DNA-protein fusions and uses thereof
AssigneeAdnexus Therapeutics, Inc.
InventorsPeter Lohse, Markus Kurz
Life of this patent
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Abstract
Disclosed herein are molecules that include a deoxyribonucleic acid (DNA) covalently bonded to a protein and uses thereof.
Claims15
A method for the selection of a desired protein or its encoding DNA, said method comprising the steps of:
- a) providing a population of candidate DNA-protein fusions, each comprising a candidate DNA covalently bonded to its encoded protein;
- and
- b) selecting a desired DNA-protein fusion, thereby selecting a desired protein or DNA.
A method for the selection of a protein, or its encoding DNA, having an altered function relative to a reference protein, said method comprising the steps of:
- a) producing a population of candidate DNA-protein fusions, each comprising a candidate DNA covalently bonded to its encoded protein and each having a protein coding sequence which differs from a reference protein coding sequence;
- and
- b) selecting a DNA-protein fusion having an altered function relative to said reference protein, thereby selecting a protein having an altered function relative to said reference protein, or its encoding DNA.
Dependencies are inferred from the claim text.