FBH58295FL, a novel human amino acid transporter and uses thereof
AssigneeMillennium Pharmaceuticals, Inc.
InventorRory A.J. Curtis
Life of this patent
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Abstract
The invention provides isolated nucleic acid molecules, designated HAAT nucleic acid molecules, which encode novel phospholipid transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HAAT nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a HAAT gene has been introduced or disrupted. The invention still further provides isolated HAAT proteins, fusion proteins, antigenic peptides and anti-HAAT antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
Claims26
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:
- 1;
- and
- (b) a nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO:
- 3.
An isolated nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
An isolated nucleic acid molecule comprising the nucleotide sequence contained in the plasmid deposited with ATCC® as Accession Number ______.
An isolated nucleic acid molecule which encodes a naturally-occurring allelic variant of a polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
An isolated nucleic acid molecule selected from the group consisting of:
- (a) a nucleic acid molecule comprising a nucleotide sequence which is at least 80% identical to the nucleotide sequence of SEQ ID NO:
- 1 or 3, or a complement thereof;
- (b) a nucleic acid molecule comprising a fragment of at least 30 nucleotides of a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 1 or 3, or a complement thereof;
- (c) a nucleic acid molecule which encodes a polypeptide comprising an amino acid sequence at least about 80% identical to the amino acid sequence of SEQ ID NO:
- 2;
- and
- (d) a nucleic acid molecule which encodes a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 10 contiguous amino acid residues of the amino acid sequence of SEQ ID NO:
- 2.
An isolated polypeptide selected from the group consisting of:
- a) a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the fragment comprises at least 10 contiguous amino acids of SEQ ID NO:
- 2;
- b) a naturally occurring allelic variant of a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, wherein the polypeptide is encoded by a nucleic acid molecule which hybridizes to complement of a nucleic acid molecule consisting of SEQ ID NO:
- 1 or 3 under stringent conditions;
- c) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 80% identical to a nucleic acid comprising the nucleotide sequence of SEQ ID NO:
- 1 or 3;
- and
- d) a polypeptide comprising an amino acid sequence which is at least 80% identical to the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.