Regulation of neural development by daedalos
AssigneeThe General Hospital Corporation
InventorBruce A. Morgan
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Abstract
The invention provides Daedalos polypeptides, nucleic acids encoding Daedalos polypeptides, and methods of using Daedalos polypeptides and nucleic acids. Also included in the invention are methods of diagnosis, methods of treatment, methods of detection, and methods of controlling neural cell differentiation by detecting and/or modulating expression of Daedalos in a cell.
Claims34
A method of identifying a neural progenitor cell, comprising:
- providing a sample of cells or tissue;
- and
- evaluating the level of expression of Daedalos in a cell of the sample,
- wherein if the cell has a higher level of expression of Daedalos as compared to a control, it is identified as a neural progenitor cell.
A method of identifying the stage of neurogenesis of a cell, comprising:
- evaluating the level of expression of Daedalos in the cell,
- wherein if the cell has a higher level of expression of Daedalos as compared to a control, it is identified as a neural progenitor cell and if the cell has a lower level of expression of Daedalos as compared to a control, it is identified as a differentiated cell.
A method of modulating cell differentiation, comprising:
- providing a cell;
- and
- modulating expression, levels or activity of Daedalos in the cell, to thereby modulate differentiation of the cell.
A method of determining if a subject is at risk for a neural cell related disorder, comprising evaluating the level of expression, protein or activity of Daedalos in a cell of the subject, wherein an aberrant level of Daedalos expression, protein or activity compared to a control is indicative of risk for a neural cell related disorder.
A method of obtaining a population of neural cells, comprising:
- providing a neural progenitor cell;
- inhibiting the expression, levels or activity of Daedalos in the neural progenitor cell;
- and
- allowing the neural progenitor cell to divide, to thereby obtain a population of neural cells.
A method of treating a neural cell related disorder in a subject, comprising:
- providing a subject having a neural cell related disorder;
- and
- modulating expression, levels or activity of Daedalos in a cell of the subject, to thereby treat the disorder.
Dependencies are inferred from the claim text.