Cryopreservation system with controlled dendritic freezing front velocity
AssigneeIntegrated Biosystems, Inc.
InventorRichard Wisniewski
Life of this patent
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Abstract
Disclosed is a biopharmaceutical material cryopreservation system that includes a flexible sterile container comprising a biocompatible polymeric material, and the flexible sterile container containing biopharmaceuticals materials, and a freezing system thermally coupled to the biopharmaceutical materials via the flexible sterile container, and the freezing system comprising a temperature sensor that monitors a temperature of the biopharmaceutical materials wherein the freezing system comprises a feedback loop constructed to control a dendritic freezing front velocity, within the biopharmaceutical materials, in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor.
Claims25
A biopharmaceutical material cryopreservation system, comprising:
- a flexible sterile container comprising a biocompatible polymeric material, and the flexible sterile container containing biopharmaceuticals materials, and;
- a freezing system thermally coupled to the biopharmaceutical materials via the flexible sterile container, and the freezing system comprising a temperature sensor that monitors a temperature of the biopharmaceutical materials
- wherein the freezing system comprises a feedback loop constructed to control a dendritic freezing front velocity, within the biopharmaceutical materials, in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor.
A method for cryopreservation of biopharmaceutical materials, comprising:
- providing a flexible sterile container comprising a biocompatible polymeric material, and the flexible sterile container containing biopharmaceuticals materials;
- thermally coupling a freezing system to the biopharmaceutical materials via the flexible sterile container, and the freezing system comprising (i) a temperature sensor that monitors a temperature of the biopharmaceutical materials, and (ii) a feedback loop constructed to control a dendritic freezing front velocity;
- and
- controlling the dendritic freezing front velocity, within the biopharmaceutical materials, in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor.
A biopharmaceutical material cryopreservation system, comprising
- flexible sterile container means for counting biopharmaceutical products, and the flexible sterile container means comprising a biocompatible polymeric material, and the flexible sterile container containing biopharmaceuticals materials, and;
- freezing means for freezing the biopharmaceutical materials, and the freezing means thermally coupled to the biopharmaceutical materials via the flexible sterile container, and the freezing means comprising a temperature sensor that monitors a temperature of the biopharmaceutical materials
- wherein the freezing means comprises a feedback loop constructed to control a dendritic freezing front velocity, within the biopharmaceutical materials, in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor.
Dependencies are inferred from the claim text.