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AssigneePurdue Research Corporation
InventorsDorothy M. Morre, D. James Morre, Raymond Cooper, Michael N. Chang
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The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a sustained release formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.
A composition of a sustained release formulation of tea catechins comprising tea catechins and at least one component which controls the release of said catechins.
A method of preventing cancer in a mammal, wherein said cancer is a type having cancer cells which express tNOX, which comprises administering to a mammal desirous of preventing cancer, an effective dose of a sustained release formulation of tea catechins so that the cancer cells which express tNOX do not accumulate to a number which creates clinical symptoms associated with said cancer.
A method for treating cancer in a mammal which comprises administering to a mammal in need of cancer treatment, wherein said cancer is a type having cancer cells which express tNOX, a therapeutically effective dose of a sustained release formulation of tea catechins so that there is a reduction in the number of cancer cells in the body.
A method for treating a solid tumor in a mammal, wherein the solid tumor comprises cancer cells which express tNOX, which comprises administering to a mammal, a therapeutically effective dose of a sustained release formulation of tea catechins so that there is a reduction in the number of cancer cells in the tumor.
A method for treating metastases in a human which comprises administering to a human having a primary cancer, wherein said cancer is a type having cancer cells which express tNOX, a therapeutically effective dose of a sustained release formulation of tea catechins so that there is a reduction in the number of cancer cells in the body.
A method for treating cancer in a mammal which comprises administering to a mammal in need of cancer treatment, wherein said cancer is a type having cancer cells which express tNOX, a therapeutically effective dose of a sustained release formulation of tea catechins, or a pharmaceutically acceptable salt thereof, in combination with an effective amount of at least one other chemotherapeutic agent so that there is a reduction in the number of cancer cells in the body.
Dependencies are inferred from the claim text.